KDM2A Protein, Human (His)

The KDM2A protein is a histone demethylase targeting "Lys-36" of histone H3. It plays a key role in the histone code, especially the demethylation of dimethylated H3 "Lys-36". Methylation. In addition to histone demethylation, KDM2A also recognizes and binds phosphorylated proteins, promoting their ubiquitination and degradation. KDM2A Protein, Human (His) is the recombinant human-derived KDM2A protein, expressed by E. coli , with N-6*His labeled tag. The total length of KDM2A Protein, Human (His) is 115 a.a., .

KDM2A Protein, a histone demethylase, assumes a pivotal role in the histone code by specifically targeting 'Lys-36' of histone H3. This enzyme exhibits a preference for demethylating the dimethylated H3 'Lys-36' residue, displaying weak or no activity towards mono- and tri-methylated H3 'Lys-36.' Beyond its histone demethylase function, KDM2A showcases versatility by recognizing and binding to certain phosphorylated proteins, promoting their ubiquitination and subsequent degradation. Essential for maintaining the heterochromatic state, KDM2A associates with centromeres, where it represses the transcription of small non-coding RNAs encoded by satellite repeat clusters, crucial for centromeric integrity and genomic stability, particularly during mitosis. Moreover, KDM2A exerts influence over circadian gene expression by suppressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer and RORA, demonstrating a catalytically-independent regulatory role in circadian rhythms. The multifaceted functions of KDM2A underscore its significance in the intricate orchestration of chromatin dynamics and cellular processes.

Human

E. coli

N-6*His

Q9Y2K7 (R567-S681)

22992

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.