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Kilon/NEGR1 Protein, Mouse (HEK293, His)

Cat. No.: HY-P75934
COA Handling Instructions

The Kilon/NEGR1 protein has been implicated in cell adhesion, suggesting a role in important cellular interactions. Its potential function as a transneuronal growth-promoting factor highlights its dynamic role in promoting regenerative axonal sprouting in the mammalian brain. Kilon/NEGR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Kilon/NEGR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kilon/NEGR1 Protein, Mouse (HEK293, His) is 287 a.a., with molecular weight of ~47 kDa.

For research use only. We do not sell to patients.

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Description

The Kilon/NEGR1 protein has been implicated in cell adhesion, suggesting a role in important cellular interactions. Its potential function as a transneuronal growth-promoting factor highlights its dynamic role in promoting regenerative axonal sprouting in the mammalian brain. Kilon/NEGR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Kilon/NEGR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kilon/NEGR1 Protein, Mouse (HEK293, His) is 287 a.a., with molecular weight of ~47 kDa.

Background

Kilon/NEGR1 Protein emerges as a potential participant in cell adhesion, suggesting a role in mediating crucial interactions for cellular processes. Additionally, its potential function as a trans-neural growth-promoting factor highlights its dynamic role in facilitating regenerative axon sprouting in the mammalian brain. The proposed involvement of Kilon/NEGR1 in regenerative processes implies its significance in promoting axon growth, particularly in the context of neural regeneration within the brain. Exploring the specific mechanisms through which Kilon/NEGR1 contributes to cell adhesion and facilitates regenerative axon sprouting may offer valuable insights into its role in neural development and regeneration. Further investigation into Kilon/NEGR1's functions could deepen our understanding of its potential implications in neuronal plasticity and regenerative processes in the mammalian brain.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

Q80Z24/NP_001034183.1 (V32-G318)

Gene ID
Molecular Construction
N-term
Kilon (V32-G318)
Accession # Q80Z24/NP_001034183.1
His
C-term
Synonyms
Neuronal growth regulator 1; Kindred of IgLON; Kilon; Neurotractin; Kiaa3001; Ntra
AA Sequence

VDFPWAAVDNMLVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTINEGTNVTLTCLATGKPEPVISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVKKVRVIVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKRLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITG

Molecular Weight

Approximately 43-55 kDa due to the glycosylation

Purity
  • Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Kilon/NEGR1 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Kilon/NEGR1 Protein, Mouse (HEK293, His)
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HY-P75934
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