LRRFIP1 Protein, Human (His, Strep)

LRRFIP1 is a transcriptional repressor that preferentially binds to GC-rich sequences (5'-AGCCCCCGGCG-3') and may regulate the expression of TNF, EGFR, and PDGFA. It inhibits PDGFA, which controls smooth muscle cell proliferation after arterial injury. LRRFIP1 Protein, Human (His, Strep) is the recombinant human-derived LRRFIP1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of LRRFIP1 Protein, Human (His, Strep) is 808 a.a., .

LRRFIP1, functioning as a transcriptional repressor, exhibits a preference for binding to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and is implicated in the potential regulation of TNF, EGFR, and PDGFA expression. This regulatory role extends to the control of smooth muscle cell proliferation following artery injury, achieved through the repression of PDGFA. Furthermore, LRRFIP1 demonstrates the capacity to bind double-stranded RNA. It plays a positive role in Toll-like receptor (TLR) signaling in response to agonists, likely by competitively interacting with the negative FLII regulator for MYD88-binding. Existing as a homodimer, LRRFIP1 may also form higher-order oligomers, and it interacts with FLII and MYD88, competing with FLII for MyD88-binding, even in the absence of lipopolysaccharide (LPS).

Human

E. coli

N-Strep;N-6*His;C-Flag

Q32MZ4 (M1-S808)

9208

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.