LSECtin/CLEC4G Protein, Human (HEK293, Fc)

LSECtin/CLEC4G Protein displays a unique carbohydrate binding profile, favoring mannose, N-acetylglucosamine (GlcNAc), and fucose in a Ca(2+)-dependent manner, as demonstrated in vitro. Notably, it serves as a receptor for Japanese encephalitis virus during microbial infection, highlighting its role in viral recognition and host-pathogen interactions. This specific carbohydrate-binding pattern underscores LSECtin/CLEC4G's molecular versatility and potential importance in immune responses to pathogens. LSECtin/CLEC4G Protein, Human (Fc) is the recombinant human-derived LSECtin/CLEC4G protein, expressed by HEK293, with N-hFc labeled tag. The total length of LSECtin/CLEC4G Protein, Human (Fc) is 239 a.a., with molecular weight of 58-66 kDa.

The LSECtin/CLEC4G Protein exhibits a distinctive carbohydrate binding profile, showing affinity for mannose, N-acetylglucosamine (GlcNAc), and fucose in a Ca(2+)-dependent manner, as observed in in vitro studies. Notably, LSECtin/CLEC4G acts as a receptor for Japanese encephalitis virus in the context of microbial infection, indicating its functional role in viral recognition and host-pathogen interactions. This specific carbohydrate-binding pattern underscores the molecular versatility of LSECtin/CLEC4G and its potential significance in immune responses to pathogens.

Human

HEK293

N-hFc

Q6UXB4 (K55-C293)

339390  [NCBI]

58-66 kDa

Greater than 85% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.2 M NaCl, 6% Trehalose, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.