1. Recombinant Proteins
  2. Others
  3. Menin Protein, Human (His, M327V)

Menin Protein, Human (His, M327V)

Cat. No.: HY-P703164
Handling Instructions

The Menin protein is an important component of the MLL/SET1 HMT complex, which methylates “Lys-4” of histone H3. It acts as a transcriptional regulator, inhibiting telomerase expression and inhibiting cell proliferation through TGFB1. Menin Protein, Human (His, M327V) is the recombinant human-derived Menin, expressed by E. coli , with His labeled tag. ,

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

The Menin protein is an important component of the MLL/SET1 HMT complex, which methylates “Lys-4” of histone H3. It acts as a transcriptional regulator, inhibiting telomerase expression and inhibiting cell proliferation through TGFB1. Menin Protein, Human (His, M327V) is the recombinant human-derived Menin, expressed by E. coli , with His labeled tag. ,

Background

Menin emerges as a pivotal component within the MLL/SET1 histone methyltransferase (HMT) complex, wielding specificity in methylating 'Lys-4' of histone H3 (H3K4) and thereby acting as a transcriptional regulator. Its regulatory influence extends to the TERT promoter, where it represses telomerase expression, and to TGFB1-mediated inhibition of cell proliferation, potentially modulating SMAD3 transcriptional activity. Menin's repertoire includes repression of JUND-mediated transcriptional activation on AP1 sites and NFKB subunit RELA, coupled with positive regulation of HOXC8 and HOXC6 gene expression. It may contribute to normal hematopoiesis by activating HOXA9 expression. Additionally, Menin's involvement in DNA repair adds another layer to its functional complexity. Within the MLL-HCF complex and the menin-associated histone methyltransferase complex, Menin collaborates with a network of proteins, such as KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, HCFC1, HCFC2, and others. Noteworthy interactions include those with POLR2B, POLR2A, FANCD2, DBF4, JUND, SMAD3, NFKB1, NFKB2, RELA, and KMT2A, highlighting the intricate web of molecular relationships that underlie Menin's diverse functions.

Species

Human

Source

E. coli

Tag

His

Accession

O00255-1 (M1-L615, M327V)

Gene ID

4221

Synonyms
SCG2
Molecular Weight

Approximately 82.87 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Menin Protein, Human (His, M327V) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Menin Protein, Human (His, M327V)
Cat. No.:
HY-P703164
Quantity:
MCE Japan Authorized Agent: