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  4. NPR1 Protein, Human (HEK293, His)

NPR1 Protein, Human (HEK293, His)

Cat. No.: HY-P703074
SDS COA Handling Instructions

NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1 Protein, Human (HEK293, His) is the recombinant human-derived NPR1 protein, expressed by HEK293 , with C-His labeled tag.

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Description

NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1 Protein, Human (HEK293, His) is the recombinant human-derived NPR1 protein, expressed by HEK293 , with C-His labeled tag.
Background

The NPR1 Protein serves as a receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP, essential vasoactive hormones that play a pivotal role in cardiovascular homeostasis. Upon binding to these ligands, NPR1 exhibits guanylate cyclase activity, initiating signaling cascades crucial for maintaining cardiovascular balance. Through its role as a receptor for these natriuretic peptides, NPR1 contributes significantly to the regulation of vascular tone and fluid balance in the cardiovascular system.
Species

Human
Source

HEK293
Tag

C-His
Accession

P16066 (G33-E473)
Gene ID

4881
Molecular Construction
N-term
NPR1 (G33-E473)
Accession # P16066
His
C-term
Synonyms
ANP-A; ANPa; Atrionatriuretic peptide receptor A; Guanylate cyclase A; Guanylate cyclase; GUC2A; NPRA
AA Sequence

GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE

Molecular Weight

Predicted band size:50.51 kDa; Observed band size: 60-75 kDa.
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
SDS (251 KB)

COA (205 KB)

Handling Instructions (2659 KB)

NPR1 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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