OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc)

The OX40 Ligand/TNFSF4 Protein, a vital member of the tumor necrosis factor family, is crucial for regulating immune responses and inflammation. Its study enhances understanding of immune modulation, offering potential applications in immunotherapy and autoimmune disease management. OX40 Ligand/TNFSF4's classification within the tumor necrosis factor family underscores its unique contributions to T cell activation and co-stimulation. Further exploration promises to enhance our knowledge of its role in both normal immune function and pathological conditions. OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293, with N-mFc labeled tag. The total length of OX40 Ligand/TNFSF4 Protein, Cynomolgus (HEK293, Fc) is 133 a.a., with molecular weight of ~48 kDa.

The OX40 Ligand/TNFSF4 Protein is a significant member of the tumor necrosis factor family, indicating its essential role in regulating immune responses and inflammatory processes. As part of this family, OX40 Ligand/TNFSF4 likely shares conserved structural and functional features with related proteins, emphasizing its involvement in signaling pathways associated with immune modulation. The classification within the tumor necrosis factor family underscores its specific designation within the broader context of cytokines, providing insights into its unique contributions to T cell activation and co-stimulation. The study of OX40 Ligand/TNFSF4 contributes to our understanding of its role in immune homeostasis, offering potential applications in immunotherapy and autoimmune disease management. Further exploration of OX40 Ligand/TNFSF4's role holds promise for enhancing our knowledge of its contributions to both normal immune function and pathological conditions.

OX4 Ligand (human, 1 ng/mL, 7 days, added into DC-T cell cultures at days and 4) inhibits the generation of IL-1-producing T cells induced by immature DCs and DCs treated with IL-1 and IFN-α^[5].

Cynomolgus

HEK293

N-mFc

F7FL80 (Q51-L183)

706255  [NCBI]

Approximately 48 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.

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  [2]. Fu N, et al. The OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases. Front Immunol. 2021 Jun 21;12:670637.  [Content Brief]

  [3]. Croft M, et al. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev. 2009 May;229(1):173-91.  [Content Brief]

  [4]. Buglio D, et al. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood. 2011 Mar 10;117(10):2910-7  [Content Brief]

  [5]. Ito T, et al, Duramad O, Hanabuchi S, Perng OA, Gilliet M, Qin FX, Liu YJ. OX40 ligand shuts down IL-10-producing regulatory T cells. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13138-43.  [Content Brief]