PCK2 Protein, Human (sf9, His-GST)

As a key enzyme in cellular metabolism, PCK2 protein catalyzes the conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP), representing the rate-limiting step in the metabolic pathway and responsible for the production of glucose from other precursors derived from lactate and citric acid. . cycle. PCK2 Protein, Human (sf9, His-GST) is the recombinant human-derived PCK2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

Phosphoenolpyruvate carboxykinase 2 (PCK2) is an enzyme that plays a crucial role in glucose metabolism by catalyzing the rate-limiting step in the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP). This metabolic pathway is significant for the synthesis of glucose from lactate and other precursors derived from the citric acid cycle. PCK2's enzymatic activity contributes to gluconeogenesis, a process crucial for maintaining glucose homeostasis, especially during fasting or periods of increased energy demand. By converting OAA to PEP, PCK2 facilitates the generation of glucose, which is essential for providing energy to various tissues, including the brain and red blood cells. It has to emphasize PCK2's pivotal role in the metabolic pathway that enables the synthesis of glucose from non-carbohydrate sources, highlighting its importance in maintaining energy balance within the cell.

Human

Sf9 insect cells

C-His;N-GST

Q16822-1/NP_004554.3 (L33-M640)

5106  [NCBI]

Approximately 94.9 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.