PGLYRP1/PGRP-S Protein, Mouse (HEK293, Fc)

PGLYRP1/PGRP-S Protein plays a vital role in the innate immune response.It recognizes bacterial peptidoglycan and activates antimicrobial defense mechanisms.PGLYRP1/PGRP-S Protein interacts with other immune molecules, enhancing immune responses against bacterial infections.Understanding its functions can aid in developing strategies to combat bacterial pathogens.PGLYRP1/PGRP-S Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PGLYRP1/PGRP-S protein, expressed by HEK293 , with C-hFc labeled tag.

PGLYRP1/PGRP-S, an innate immunity protein, serves multifaceted roles in antimicrobial and antitumor defense systems. Functioning as a pattern receptor, it binds to murein peptidoglycans (PGN) from Gram-positive bacteria, thereby exerting bactericidal activity. Additionally, it forms an equimolar complex with heat shock protein HSPA1A, triggering programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor. Collaborating with the Ca(2+)-binding protein S100A4, it acts as a chemoattractant that induces lymphocyte movement and activates lymphocytes to eliminate virus-infected and tumor cells. The induction of cytotoxicity on monocyte surfaces requires interaction with the TREM1 receptor. This protein exhibits a homodimeric structure linked by disulfide bonds and interacts intricately with HSPA1A and HSPBP1, modulating its cytotoxic activity. These versatile functions underscore the critical involvement of PGLYRP1/PGRP-S in immune response and defense mechanisms.

Mouse

HEK293

C-hFc

O88593 (F19-E182)

21946  [NCBI]

50-55 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Solution

Supplied as a 0.22 μm filtered solution of PBS, 10% glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.