PTK9 Protein, Human (His-GST)

PTK9, an actin-binding protein, regulates motility and morphological processes by inhibiting actin polymerization and capping the barbed ends of filaments. It plays a crucial role in clathrin-mediated endocytosis and the distribution of endocytic organelles. PTK9 interacts with G-actin, capping protein (CP), and possibly TWF2 and phosphoinositides, particularly PI(4,5)P2, which down-regulates its activity. Additionally, it interacts with ACTG1. PTK9 Protein, Human (His-GST) is the recombinant human-derived PTK9 protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of PTK9 Protein, Human (His-GST) is 252 a.a., with molecular weight of ~50 kDa.

PTK9, an actin-binding protein, actively participates in motile and morphological processes, exerting its influence on actin polymerization by likely sequestering G-actin. Through its capacity to cap the barbed ends of filaments, PTK9 plays a regulatory role in cellular motility. Furthermore, its involvement in clathrin-mediated endocytosis and the distribution of endocytic organelles suggests a multifaceted role in cellular dynamics. PTK9 interacts with G-actin, particularly the ADP-actin form, and with capping protein (CP), highlighting its intricate involvement in actin-related processes. Additionally, it may have interactions with TWF2 and phosphoinositides, particularly PI(4,5)P2, where binding to the latter results in down-regulation. Moreover, PTK9 has been observed to interact with ACTG1, further expanding its network of molecular associations.

Human

E. coli

N-His;N-GST

Q12792-4 (M1-D252)

5756  [NCBI]

Approximately 50 kDa

Greater than 84% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.