SLC11A1 Protein, Human (Sf9, His, MBP, FLAG)

The SLC11A1 protein is a macrophage-specific antiporter that transports metal ions reversibly through proton gradients. It localizes to late endosomal lysosomal membranes and transports divalent cations into acidic compartments, affecting antibacterial activity. SLC11A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC11A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC11A1 Protein, Human (Sf9, His, MBP, FLAG) is 549 a.a., .

SLC11A1 Protein, a macrophage-specific antiporter, facilitates bidirectional metal ion transport against a proton gradient. Positioned on late endosomal lysosomal membranes, it transfers bivalent cations from the cytosol into these acidic compartments, impacting antimicrobial activity directly. Notably involved in iron metabolism, it plays a crucial role in the host's innate resistance to intracellular parasites. This resistance mechanism involves sequestering Fe(2+) and Mn(2+), essential cofactors for both prokaryotic and eukaryotic catalases and superoxide dismutases. The sequestration serves a dual purpose, protecting macrophages from reactive oxygen species and denying pathogens the essential cations for synthesizing their protective enzymes (Probable).

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

P49279 (T2-G550)

6556

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.