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SLC15A2 Protein, Human (Sf9, His, MBP, FLAG)

Cat. No.: HY-P702018
Handling Instructions Technical Support

The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC15A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC15A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

For research use only. We do not sell to patients.

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Description

The SLC15A2 protein is a proton-coupled amino acid transporter that prefers dipeptides and transports oligopeptides containing 2 to 4 amino acids. The stoichiometric ratio of protons to peptides is 2:1 or 3:1, which helps the kidneys absorb dipeptides and tripeptides. SLC15A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC15A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

Background

SLC15A2 protein, a proton-coupled amino-acid transporter, demonstrates a preference for transporting oligopeptides containing 2 to 4 amino acids, with a notable affinity for dipeptides. Its transport activity involves a proton to peptide stoichiometry of 2:1 or 3:1, facilitating the absorption of circulating di- and tripeptides from the glomerular filtrate within the kidney. Beyond its role in peptide transport, SLC15A2 exhibits versatility by transporting various substances, including beta-lactam antibiotics like cefadroxil, other antiviral and anticancer drugs, the dipeptide-like aminopeptidase inhibitor bestatin, and carnosine. Notably, its involvement in innate immunity extends to promoting the detection of microbial pathogens by NOD-like receptors (NLRs), and it mediates the transport of bacterial peptidoglycans across cellular membranes, such as muramyl dipeptide (MDP), a ligand for NOD2, particularly in macrophages.

Species

Human

Source

Sf9 insect cells

Tag

N-MBP;C-Flag;N-8*His

Accession

Q16348 (N2-L729)

Gene ID

6565

Molecular Construction
N-term
8*His-MBP
SLC15A2 (N2-L729)
Accession # Q16348
Flag
C-term
Synonyms
SLC15A2; Solute carrier family 15 member 2; Kidney H(+)/peptide cotransporter; Oligopeptide transporter; kidney isoform; Peptide transporter 2
Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

SLC15A2 Protein, Human (Sf9, His, MBP, FLAG) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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SLC15A2 Protein, Human (Sf9, His, MBP, FLAG)
Cat. No.:
HY-P702018
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