SLC29A1 Protein, Human (Sf9, His, MBP, FLAG)

The SLC29A1 protein is an important uniporter that actively promotes the transport of nucleosides and nucleobases and maintains cellular homeostasis of essential compounds. As a Na(+)-independent transporter, SLC29A1 efficiently transports a series of nucleosides and nucleobases, including adenosine, guanosine, inosine, uridine, thymidine, cytidine, hypoxanthine, adenine, guanine, Thymine and uracil. SLC29A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC29A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC29A1 Protein, Human (Sf9, His, MBP, FLAG) is 455 a.a., .

SLC29A1, a pivotal uniporter, intricately contributes to the facilitative transport of nucleosides and nucleobases, playing a crucial role in maintaining cellular homeostasis for these essential compounds. Functioning as a Na(+)-independent transporter, SLC29A1 is actively involved in transporting a spectrum of nucleosides, including adenosine, guanosine, inosine, uridine, thymidine, and cytidine. Moreover, it efficiently transports both purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). This versatile transporter is instrumental in mediating basolateral nucleoside uptake into Sertoli cells, thereby regulating nucleoside transport in the testis across the blood-testis barrier. Notably, SLC29A1 assumes a pivotal role in the regulation of inosine levels in brown adipocytes tissues (BAT), thereby influencing BAT-dependent energy expenditure. The broad substrate specificity and tissue-specific functions highlight the significance of SLC29A1 in cellular nucleoside transport and metabolic processes.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q99808 (T2-V456)

2030

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.