1. Recombinant Proteins
  2. Others
  3. SLPI Protein, Human (HEK293, Fc)

SLPI Protein, Human (HEK293, Fc)

Cat. No.: HY-P78548
Handling Instructions

SLPI Protein, an acid-stable proteinase inhibitor, demonstrates strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G in various studies. It crucially modulates inflammatory and immune responses post-bacterial infection and L.major infection. SLPI down-regulates responses to bacterial lipopolysaccharide (LPS), regulates NF-kappa-B activation, impacting inflammatory responses. It exhibits antimicrobial activity against mycobacteria, contributing to resistance against M.tuberculosis. Essential for normal resistance to L.major infection, SLPI plays a vital role in wound healing, preventing tissue damage by regulating protease activity. Collaborating with ELANE, SLPI is necessary for normal bone marrow myeloid cell differentiation and proliferation, interacting with GRN to protect progranulin from proteolysis. SLPI Protein, Human (HEK293, Fc) is the recombinant human-derived SLPI protein, expressed by HEK293, with C-hFc labeled tag. The total length of SLPI Protein, Human (HEK293, Fc) is 107 a.a., with molecular weight of 40-50 kDa.

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

SLPI Protein, an acid-stable proteinase inhibitor, demonstrates strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G in various studies. It crucially modulates inflammatory and immune responses post-bacterial infection and L.major infection. SLPI down-regulates responses to bacterial lipopolysaccharide (LPS), regulates NF-kappa-B activation, impacting inflammatory responses. It exhibits antimicrobial activity against mycobacteria, contributing to resistance against M.tuberculosis. Essential for normal resistance to L.major infection, SLPI plays a vital role in wound healing, preventing tissue damage by regulating protease activity. Collaborating with ELANE, SLPI is necessary for normal bone marrow myeloid cell differentiation and proliferation, interacting with GRN to protect progranulin from proteolysis. SLPI Protein, Human (HEK293, Fc) is the recombinant human-derived SLPI protein, expressed by HEK293, with C-hFc labeled tag. The total length of SLPI Protein, Human (HEK293, Fc) is 107 a.a., with molecular weight of 40-50 kDa.

Background

SLPI, an acid-stable proteinase inhibitor, exhibits robust affinities for trypsin, chymotrypsin, elastase, and cathepsin G, as demonstrated in various studies. It plays a crucial role in modulating inflammatory and immune responses following bacterial infection, as well as infection by the intracellular parasite L.major. Additionally, SLPI contributes to down-regulating responses to bacterial lipopolysaccharide (LPS) (By similarity) and is involved in regulating the activation of NF-kappa-B, thereby influencing inflammatory responses. Notably, SLPI exhibits antimicrobial activity against mycobacteria but not against salmonella, contributing to normal resistance against infection by M.tuberculosis. It is also essential for normal resistance to infection by L.major and plays a critical role in wound healing, likely by preventing tissue damage through the regulation of protease activity (By similarity). Furthermore, in collaboration with ELANE, SLPI is required for the normal differentiation and proliferation of bone marrow myeloid cells, and it interacts with GRN, protecting progranulin from proteolysis.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

P03973 (S26-A132)

Gene ID
Molecular Construction
N-term
SLPI (S26-A132)
Accession # P03973
hFc
C-term
Synonyms
ALP; BLPI; HUSI-1; MPI; WAP4; WFDC4; ALK1; HUSI; SLPI
Molecular Weight

40-50 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

SLPI Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SLPI Protein, Human (HEK293, Fc)
Cat. No.:
HY-P78548
Quantity:
MCE Japan Authorized Agent: