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  3. Transferases (EC 2)
  4. STK4 Protein, Human (His)

MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. STK4 Protein, Human (His) is the recombinant human-derived STK4, expressed by E. coli , with His labeled tag. ,

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Description

MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. STK4 Protein, Human (His) is the recombinant human-derived STK4, expressed by E. coli , with His labeled tag. ,

Background

MST1/STK4 protein is a stress-activated, pro-apoptotic kinase with diverse cellular functions, including a critical role in the Hippo signaling pathway. Following caspase-cleavage, MST1/STK4 enters the nucleus, inducing chromatin condensation and internucleosomal DNA fragmentation, contributing to apoptosis. In the Hippo pathway, MST1/STK4, along with its regulatory protein SAV1, forms a kinase cascade that phosphorylates and activates LATS1/2-MOB1 complex. This, in turn, phosphorylates and inactivates the YAP1 oncoprotein and WWTR1/TAZ, regulating genes involved in proliferation, cell death, and cell migration. MST1/STK4 is essential for repressing hepatocyte proliferation, inhibiting facultative adult liver stem cells, and preventing tumor formation. Additionally, it plays a role in histone modification during apoptosis, phosphorylates various substrates like FOXO3, MOBKL1A, MOBKL1B, RASSF2, TNNI3, and FOXO1, influencing diverse cellular processes such as transcription, cell death initiation, and signaling pathways like PKB/AKT1 and AR. Notably, MST1/STK4 acts as an inhibitor of PKB/AKT1, and its phosphorylation of SIRT1 promotes p53-dependent transcription and apoptosis in response to DNA damage. Furthermore, it intersects with PKB/AKT1 signaling to suppress AR activity by antagonizing the formation of AR-chromatin complexes.

Species

Human

Source

E. coli

Tag

His

Accession

Q13043-1 (E2-E311)

Gene ID

6789

Synonyms
STK4; serine/threonine kinase 4; serine/threonine-protein kinase 4; kinase responsive to stress 2; KRS2; mammalian sterile 20 like 1; MST1; yeast Ste20 like; YSK3; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); DKFZp686A2068
Purity

Greater than 80 % as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

STK4 Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
STK4 Protein, Human (His)
Cat. No.:
HY-P702744
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