Thrombomodulin Protein, Human (HEK293, His, solution)

Thrombomodulin, an endothelial cell receptor, forms a 1:1 complex with thrombin, vital for coagulation regulation. This complex activates protein C, converting it to protein Ca. Protein Ca then inhibits the activated cofactors (factor Va and factor VIIIa) of the coagulation cascade, suppressing thrombin generation. Thrombomodulin's interaction with ITGAL, ITGAM, and ITGB2 emphasizes its role in immune response modulation. Thrombomodulin Protein, Human (HEK293, His, solution) is the recombinant human-derived Thrombomodulin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Thrombomodulin Protein, Human (HEK293, His, solution) is 497 a.a., with molecular weight of ~72 kDa.

Thrombomodulin, a distinctive endothelial cell receptor, establishes a precise 1:1 stoichiometric complex with thrombin, playing a crucial role in the regulation of coagulation. This complex facilitates the conversion of protein C to its activated form, protein Ca. Once activated, protein Ca acts by cleaving the activated cofactors of the coagulation cascade, namely factor Va and factor VIIIa, effectively curbing the generation of thrombin. Thrombomodulin's interaction with ITGAL, ITGAM, and ITGB2 further underscores its involvement in modulating immune responses.

Human

HEK293

C-6*His

P07204 (A19-S515)

7056  [NCBI]

APAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHS

Approximately 72 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.