TIE-2 Protein, Cynomolgus (HEK293, Fc)

TIE-2 belongs to the RTPK family of proteins and is a type I transmembrane protein. TIE-2 can serve as a receptor for growth factors, differentiation factors, and metabolic response stimulators. TIE-2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIE-2 Protein, Cynomolgus (HEK293, Fc) is 723 a.a., with molecular weight of ~130 kDa.

TIE-2 belongs to the RTPK family of proteins and is a type I transmembrane protein. TIE-2 can serve as a receptor for growth factors, differentiation factors, and metabolic response stimulators^[1].

Immobilized Cynomolgus TIE-2 at 1 μg/mL (100 μL/well) can bind Biotinylated Angiopoietin-2. The ED₅₀ for this effect is 88.60 ng/mL.

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  Immobilized Cynomolgus TIE-2 at 1 μg/mL (100 μL/well) can bind Biotinylated Angiopoietin-2. The ED₅₀ for this effect is 88.60 ng/mL.

Cynomolgus

HEK293

C-hFc

G7PS68 (A23-K745)

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AMDLILINSLPLVSDAETSLTCIASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNRLCTVCVNNGVCHEDTGECICPPGFMGRTCEKACERHTFGRTCKERCSGQDGCKSYVFCLPDPYGCSCATGWKGLQCNEACHHGFYGPDCKLRCSCSNGETCDRFQGCLCSPGRQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSANTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWRHIQVTNEIVTLNHLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHIDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESEAPADLGGGK

Approximately 130 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.