TL1A/TNFSF15 Protein, Mouse (Biotinylated, HEK293, His-Avi)

TL1A/TNFSF15 Protein, a receptor for TNFRSF25 and TNFRSF6B, crucially activates NF-kappa-B signaling. It promotes caspase activation for apoptosis and exhibits anti-angiogenic properties, inhibiting vascular endothelial growth and angiogenesis in vitro. The protein contributes to splenocyte alloactivation, emphasizing its significance in immune responses. Functioning as a homotrimer, TL1A/TNFSF15 reflects its structural arrangement in these cellular processes. TL1A/TNFSF15 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived TL1A/TNFSF15 protein, expressed by HEK293, with N-His, N-Avi labeled tag. The total length of TL1A/TNFSF15 Protein, Mouse (Biotinylated, HEK293, His-Avi) is 192 a.a., with molecular weight of 28-38 kDa.

The TL1A/TNFSF15 protein serves as the receptor for TNFRSF25 and TNFRSF6B, playing a crucial role in mediating the activation of NF-kappa-B signaling. Beyond its involvement in apoptosis by promoting the activation of caspases, TL1A/TNFSF15 exhibits anti-angiogenic properties, inhibiting vascular endothelial growth and angiogenesis in vitro. Furthermore, the protein contributes to splenocyte alloactivation, underscoring its significance in immune responses. TL1A/TNFSF15 functions as a homotrimer, reflecting its structural arrangement in these cellular processes.

Immobilized Mouse DR3, His Tag at 1 μg/mL(100 μl/well) on the plate. Dose response curve for Biotinylated Mouse TNFSF15, His Tag with the EC₅₀ of ≤16.8 ng/mL determined by ELISA.

Mouse

HEK293

N-His;N-Avi

Q5UBV8 (A61-L252)

326623  [NCBI]

28-38 kDa

Greater than 90% as determined by SEC-HPLC.

Lyophilized powder

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.