TYRO3 Protein, Human (Biotinylated, sf9, Flag, Avi)

TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as TULP1 or GAS6. TYRO3 is activated by ligand binding and regulates cell survival, migration, and differentiation, leading to dimerization and intracellular autophosphorylation to create docking sites for downstream signaling molecules. TYRO3 Protein, Human (Biotinylated, sf9, Flag, Avi) is the recombinant human-derived TYRO3, expressed by Sf9 insect cells , with Avi, Flag labeled tag. ,

The TYRO3/DTK protein is a receptor tyrosine kinase that transmits signals from the extracellular matrix to the cytoplasm by binding to ligands such as TULP1 or GAS6. It regulates various physiological processes including cell survival, migration, and differentiation. When ligands bind to TYRO3 at the cell surface, it leads to dimerization and autophosphorylation of its intracellular domain, creating docking sites for downstream signaling molecules. This activation also interacts with PIK3R1, enhancing PI3-kinase activity and activating the AKT survival pathway. This pathway includes nuclear translocation of NF-kappa-B and up-regulation of NF-kappa-B-regulated genes. TYRO3 signaling is involved in protecting neurons from excitotoxic injury, promoting platelet aggregation, and reorganizing the cytoskeleton. Additionally, TYRO3 plays a crucial role in inhibiting the innate immune response triggered by Toll-like receptors (TLRs) by activating STAT1, which selectively induces the production of suppressors of cytokine signaling SOCS1 and SOCS3. It is also noteworthy that TYRO3 functions as a receptor for lassa virus and lymphocytic choriomeningitis virus, potentially through GAS6 binding to phosphatidyl-serine on the surface of the virion envelope.

Human

Sf9 insect cells

Avi;Flag

Q06418 (K453-C890)

7301

Greater than 80 % as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.