USP51 Protein, Human (Sf9)

The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (Sf9) is the recombinant human-derived USP51 protein, expressed by Sf9 insect cells , with tag free. The total length of USP51 Protein, Human (Sf9) is 344 a.a., .

USP51 protein plays a distinctive role in the regulation of the DNA damage response by specifically deubiquitinating 'Lys-14' (H2AK13Ub) and 'Lys-16' (H2AK15Ub) residues of histone H2A at double-strand breaks (DSBs). Following DNA damage, USP51 is recruited to chromatin, where it actively modulates the dynamic assembly and disassembly of TP53BP1 and BRCA1, crucial players in DNA repair processes. In addition to its role in histone H2A deubiquitination, USP51 exhibits activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin, further expanding its impact on the ubiquitin signaling pathway. The intricate involvement of USP51 in these molecular processes underscores its significance in orchestrating the DNA damage response and highlights its potential as a key player in maintaining genomic integrity.

Human

Sf9 insect cells

Tag Free

Q70EK9 (R363-Q706)

158880

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.