2. Autophagy MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. VEGFR Autophagy PDGFR Raf RET c-Kit FGFR Tie
  4. Regorafenib (Standard)

Regorafenib (Standard) 

Cat. No.: HY-10331R Purity: ≥98%
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Regorafenib (Standard) is the analytical standard of Regorafenib. This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib shows very robust antitumor and antiangiogenic activity.

For research use only. We do not sell to patients.

Regorafenib (Standard) Chemical Structure

Regorafenib (Standard) Chemical Structure

CAS No. : 755037-03-7

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Description
Molecular Weight

482.82

Formula

C21H15ClF4N4O3
CAS No.
SMILES

O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Regorafenib (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Regorafenib (Standard)755037-03-7VEGFRAutophagyPDGFRRafRETc-KitFGFRTieVascular endothelial growth factor receptorPlatelet-derived growth factor receptorRaf kinasesSCFRCD117Fibroblast growth factor receptorAngiopoietin receptorAntitumorigenicantiangiogenictumorHUVECsHep3B cellHAoSMCsNIH-3T3Colo-205MDA-MB-231786-OInhibitorinhibitorinhibit

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