rel-Levormeloxifene (Synonyms: rel-L-Centchroman; Ormeloxifene)

Cat. No.: HY-122359A: FAQs
Data Sheet Handling Instructions

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rel-Levormeloxifene (rel-L-Centchroman) is the relative configuration of Levormeloxifene (HY-122359). rel-Levormeloxifene is a selective estrogen receptor modulator (SERM). rel-Levormeloxifene inhibits proliferation of leukemia cells with IC₅₀ about 7 μM, arrests cell cycle at G0/G1 phase, and induces apoptosis. rel-Levormeloxifene induces differentation of myelogenesis leukemia, and enhances ROS production in K562 cells.

For research use only. We do not sell to patients.

rel-Levormeloxifene Chemical Structure

CAS No. : 31477-60-8

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Other Forms of rel-Levormeloxifene:

Levormeloxifene Get quote
Levormeloxifene fumarate Get quote

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Description	rel-Levormeloxifene (rel-L-Centchroman) is the relative configuration of Levormeloxifene (HY-122359). rel-Levormeloxifene is a selective estrogen receptor modulator (SERM). rel-Levormeloxifene inhibits proliferation of leukemia cells with IC₅₀ about 7 μM, arrests cell cycle at G0/G1 phase, and induces apoptosis. rel-Levormeloxifene induces differentation of myelogenesis leukemia, and enhances ROS production in K562 cells^[1].
Molecular Weight	457.60
Formula	C₃₀H₃₅NO₃
CAS No.	31477-60-8
SMILES	CC1(C)[C@@H](C2=CC=CC=C2)[C@H](C3=CC=C(OCCN4CCCC4)C=C3)C5=CC=C(OC)C=C5O1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (285 KB) Handling Instructions (2659 KB)
References	[1]. Pooja PAL, et al., An anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells. WO2015044950.

rel-Levormeloxifene Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

rel-Levormeloxifene31477-60-8rel-L-Centchroman OrmeloxifeneEstrogen Receptor/ERRApoptosisReactive Oxygen SpeciesK562U937HL60HEK293Tleukemiaanti-leukemiaSERMInhibitorinhibitorinhibit

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