2. Anti-infection Apoptosis
  3. Antibiotic Apoptosis Bacterial
  4. Resistomycin

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.

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Resistomycin Chemical Structure

Resistomycin Chemical Structure

CAS No. : 20004-62-0

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Resistomycin Related Antibodies

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Description

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
0.5 μM
Compound: 5
Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
CCRF-CEM IC50
0.5 μM
Compound: 1
Antiproliferative activity against human CEM cells after 72 hrs by MTT assay
Antiproliferative activity against human CEM cells after 72 hrs by MTT assay
[PMID: 29137865]
HCT-116 IC50
0.1 μM
Compound: 1
Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay
[PMID: 29137865]
HCT-116 IC50
0.3 μM
Compound: 1
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 29137865]
HeLa IC50
0.1 μM
Compound: 5
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
HeLa IC50
0.1 μM
Compound: 1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 29137865]
HMEC-1 IC50
0.5 μM
Compound: 5
Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
HMEC-1 IC50
0.5 μM
Compound: 1
Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay
Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay
[PMID: 29137865]
K562 IC50
0.3 μM
Compound: 1
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 29137865]
L1210 IC50
0.7 μM
Compound: 5
Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 33974416]
L1210 IC50
0.7 μM
Compound: 1
Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay
[PMID: 29137865]
T-24 IC50
26 μM
Compound: 1
Growth inhibition of human T24 cells after 72 hrs by cell impedance method
Growth inhibition of human T24 cells after 72 hrs by cell impedance method
[PMID: 29137865]
In Vitro

Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation[1].
Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1].
Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1].
Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Resistomycin Related Antibodies
Molecular Weight

376.36

Formula

C22H16O6
CAS No.
SMILES

OC1=C(C(C2=C(O)C=C(C)C(C(O)=C3)=C2C4=C3C(C)(C)C5=O)=O)C4=C5C(O)=C1
Structure Classification
Initial Source

Streptomyces sulphureus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Resistomycin Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resistomycin20004-62-0AntibioticApoptosisBacterialapoptosiscell cycle arrestTNBCSNAILSLUGInhibitorinhibitorinhibit

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