Rivanicline fumarate  (Synonyms: RJR-2403 fumarate; (E)-Metanicotine fumarate)

Rivanicline fumarate is a neuronal nicotinic receptor (neuronal nicotinic receptor) agonist that is highly selective for the α4β2 subtype,K_i is 26 nM, which is more than 1000 times more inhibitory than α7 receptor^[1].

278.30

C₁₄H₁₈N₂O₄

183288-99-5

CNCC/C=C/C1=CC=CN=C1.O=C(O)/C=C/C(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.  [Content Brief]

  [2]. Lippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.  [Content Brief]

  [3]. Damaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.  [Content Brief]