2. GPCR/G Protein
  3. G protein-coupled Bile Acid Receptor 1
  4. RO5527239

RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificially secrets the endogenous hormone GLP-2.

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RO5527239 Chemical Structure

RO5527239 Chemical Structure

CAS No. : 1354812-99-9

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Description

RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificially secrets the endogenous hormone GLP-2[1].

In Vivo

RO5527239 (30 mg/kg, p.o. for 10 days) stimulates the TGR5 receptor, upregulates L cells and L cells hormone GLP-2, triggers a GLP-2-dependent intestinal adaption in C57BL/6N mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GLP-2r-/- and GLP-2r+/+ C57Bl/6N mice[1]
Dosage: 30 mg/kg
Administration: p.o. for 10 days
Result: Increased GLP-1 and GLP-2 concentrations in the colon, gallbladder weight with both genotype. Increased villus height in the duodenum and decreased colon length in GLP-2r+/+ mice.
Molecular Weight

457.56

Formula

C28H31N3O3
CAS No.
SMILES

O=C(C1CCN(C2=CC=C([C@H](C3=CC=CC=C3C)C/C(C4=CC(C)=NC=C4)=N\O)C=C2)CC1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RO5527239 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO55272391354812-99-9RO 5527239RO-5527239G protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1takeda G protein-receptor-5orally activeC57BL/6N mouseInhibitorinhibitorinhibit

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HY-116453
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