Roseltide rT1 

Roseltide rT1 is a neutrophil elastase inhibitor (IC₅₀=0.47 μM) rich in cysteine and one of the Roseltide (rT1-rT8) family members. Roseltide rT1 improves cAMP accumulation stimulated by neutrophil elastase in vitro, showing potential for inhibiting related diseases^[1].

2622.16

C₁₁₀H₁₇₇N₃₁O₃₁S₆

2206692-95-5

Cys-Ile-Pro-Arg-Gly-Gly-Ile-Cys-Leu-Val-Ala-Leu-Ser-Gly-Cys-Cys-Asn-Ser-Pro-Gly-Cys-Ile-Phe-Gly-Ile-Cys-Ala (Disulfide bridge: Cys1-Cys16, Cys8-Cys21, Cys15-Cys26)

CIPRGGICLVALSGCCNSPGCIFGICA (Disulfide bridge: Cys1-Cys16, Cys8-Cys21, Cys15-Cys26)

O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N2[C@H](C(NC3)=O)CCC2)=O)CO)=O)CC(N)=O)=O)N[C@H](C(N4[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]1CSSC[C@H](NC5=O)C(N[C@H](C(O)=O)C)=O)=O)=O)CO)=O)CC(C)C)=O)C)=O)C(C)C)=O)CC(C)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]5[C@H](CC)C)=O)=O)CC6=CC=CC=C6)=O)[C@H](CC)C)=O)=O)[C@H](CC)C)=O)=O)=O)CCCNC(N)=N)=O)CCC4)=O)[C@H](CC)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Loo S, et al. Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa. Sci Rep. 2016 Dec 19;6:39401.  [Content Brief]