2. Epigenetics
  3. Epigenetic Reader Domain
  4. RX-37

RX-37 is a selective BET inhibitor. RX-37 binds to BET bromodomain proteins (BRD2, BRD3, and BRD4) with Ki values of 3.2-24.7 nM. RX-37 can be used for research of cancers.

For research use only. We do not sell to patients.

RX-37 Chemical Structure

RX-37 Chemical Structure

CAS No. : 1627715-60-9

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RX-37 Related Antibodies

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Description

RX-37 is a selective BET inhibitor. RX-37 binds to BET bromodomain proteins (BRD2, BRD3, and BRD4) with Ki values of 3.2-24.7 nM. RX-37 can be used for research of cancers[1].

IC50 & Target

Ki: 11.1 nM, 11.7 nM, 7.3 nM, 3.2 nM, 24.7 nM, 12.2 nM (BRD2, BRD3, and BRD4 BD1 and BD2)[1].
Cellular Effect
Cell Line Type Value Description References
K562 IC50
> 2000 nM
Compound: 18
Cytotoxicity against human K562 cells harboring BCR-ABL fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human K562 cells harboring BCR-ABL fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
[PMID: 26080064]
MOLM-13 IC50
66 nM
Compound: 18
Cytotoxicity against human MOLM13 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human MOLM13 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
[PMID: 26080064]
MOLM-13 IC50
66 nM
Compound: 6; RX-37
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
[PMID: 28463487]
MV4-11 IC50
20 nM
Compound: 18
Cytotoxicity against human MV4-11 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human MV4-11 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
[PMID: 26080064]
MV4-11 IC50
20 nM
Compound: 6; RX-37
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
[PMID: 28463487]
Molecular Weight

413.47

Formula

C24H23N5O2
CAS No.
SMILES

COC1=CC2=C(NC3=C2C(C4=C(C)NN=C4C5CC5)=NC=C3)C=C1C6=C(C)ON=C6C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RX-37 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX-371627715-60-9RX37RX 37Epigenetic Reader DomainCancerbromodomainInhibitorinhibitorinhibit

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HY-19549
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