RXFP2 agonist 2

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RXFP2 agonist 2 is a selective，orally active and allosteric RXFP2 agonist with an EC₅₀ value of 0.38 µM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis.

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RXFP2 agonist 2 Chemical Structure

CAS No. : 2971704-85-3

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5 mg	USD 570	Ask For Quote & Lead Time
10 mg	USD 920	Ask For Quote & Lead Time
25 mg	USD 1850	Ask For Quote & Lead Time
50 mg	USD 3000	Ask For Quote & Lead Time
100 mg	USD 4800	Ask For Quote & Lead Time

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Description

IC₅₀ & Target

EC₅₀: 0.38 µM (RXFP2)^[1]

In Vitro

RXFP2 agonist 2 (Compound 6641) (1, 3, 5 µM; 14 days) induces osteoblast mineralization at 3 and 5 µM with no cytotoxicity in HCO cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HCO cells
Concentration:	0-100 µM
Incubation Time:	14 days
Result:	Induced mineralization of primary human osteoblasts and is non-cytotoxic.

In Vivo

RXFP2 agonist 2 (10 mg/kg; p.o.; 3 times per week for 8 weeks) promotes bone formation in female mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-week-old WT C57BL/6 J female mice^[1]
Dosage:	3 mg/kg for i.v.; 10 mg/kg for p.o.
Administration:	I.v. or p.o.
Result:	Exhibited a half-life of between 4-6.5 h depending on the route of administration, with no accumulation at 10 mg/kg, and oral bioavailability around 25-31%.

Animal Model:	8-week-old WT C57BL/6 J female mice^[1]
Dosage:	10 mg/kg
Administration:	P.o.; 3 times per week for 8 weeks
Result:	Increased bone formation in mouse with significantly increased in Tb.N and Tb.Th, and increased BV/TV and decreased Tb.Sp.

Molecular Weight

787.37

Formula

C₂₉H₁₉F₉IN₃O₅

CAS No.

2971704-85-3

SMILES

O=C(N1[C@H]2CN(CC1)C(COC3=CC=C(C=C3I)OC(F)(F)F)=O)C4=CC(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=CC=C4NC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Esteban-Lopez M, et al. Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2. Commun Biol. 2022 Nov 4;5(1):1183. [Content Brief]

RXFP2 agonist 2 Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RXFP2 agonist 22971704-85-3RXFP ReceptorHCO cellsfemale miceosteoblast mineralizationbone formationInhibitorinhibitorinhibit

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