2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG3-propionic acid

(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

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(S,R,S)-AHPC-PEG3-propionic acid Chemical Structure

(S,R,S)-AHPC-PEG3-propionic acid Chemical Structure

CAS No. : 2140807-42-5

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-PEG3-propionic acid Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

VHL

 

Molecular Weight

662.79

Formula

C32H46N4O9S
CAS No.
Appearance

Liquid (Density: 1.264±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCOCCOCCOCCC(O)=O)=O)=O)C[C@H](O)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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(S,R,S)-AHPC-PEG3-propionic acid Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG3-propionic acid2140807-42-5E3 Ligase Ligand-Linker ConjugatesE3-ligasesynthesized(S,R,S)-AHPCPROTACInhibitorinhibitorinhibit

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