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  4. S0456

S0456 is a near-infrared (NIR) fluorescent dye that can be used for synthesize Pafolacianine (HY-139579). S0456 binds to the folate receptor (FR). S0456 can be used as a tumor-specific optical imaging agent. The excitation wavelength is 788 nM and emission wavelength is 800 nM.

For research use only. We do not sell to patients.

S0456 Chemical Structure

S0456 Chemical Structure

CAS No. : 1252007-83-2

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5 mg USD 240 In-stock
10 mg USD 385 In-stock
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Description

S0456 is a near-infrared (NIR) fluorescent dye that can be used for synthesize Pafolacianine (HY-139579). S0456 binds to the folate receptor (FR). S0456 can be used as a tumor-specific optical imaging agent. The excitation wavelength is 788 nM and emission wavelength is 800 nM[1].

Molecular Weight

953.44

Formula

C38H44ClN2Na3O12S4
CAS No.
Appearance

Solid

Color

Green to dark green

SMILES

O=[S](CCCCN(/C1=C/C=C(CCC2)/C(Cl)=C2/C=C/C(C(C)(C3=C4)C)=[N+](C3=CC=C4[S](=O)([O-])=O)CCCC[S](=O)(O[Na])=O)C(C(C1(C)C)=C5)=CC=C5[S](=O)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (34.96 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0488 mL 5.2442 mL 10.4883 mL
5 mM 0.2098 mL 1.0488 mL 2.0977 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.33%

SDS (252 KB)

COA (253 KB) HNMR (317 KB) RP-HPLC (211 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0488 mL 5.2442 mL 10.4883 mL 26.2208 mL
5 mM 0.2098 mL 1.0488 mL 2.0977 mL 5.2442 mL
10 mM 0.1049 mL 0.5244 mL 1.0488 mL 2.6221 mL
15 mM 0.0699 mL 0.3496 mL 0.6992 mL 1.7481 mL
20 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.3110 mL
25 mM 0.0420 mL 0.2098 mL 0.4195 mL 1.0488 mL
30 mM 0.0350 mL 0.1748 mL 0.3496 mL 0.8740 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S04561252007-83-2S 0456S-0456Fluorescent DyeNIRPafolacianinecanceroptical imaging agentInhibitorinhibitorinhibit

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