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  4. S0456

S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents.

For research use only. We do not sell to patients.

S0456 Chemical Structure

S0456 Chemical Structure

CAS No. : 1252007-83-2

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S0456 Related Antibodies

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Description

S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents[1].

In Vitro

In the design of OTL38 (HY-139579), S0456 is linked to the modified folic acid. S0456 not only serves as part of the ligand that binds to the folate receptor but also increases the delocalized electron system of the near-infrared dye to enhance fluorescence. The introduction of a phenoxy group via a vinyl ether bridge to S0456 can further enhance the fluorescence intensity and cause a blue shift in the spectrum. Ultimately, this imparts OTL38 (HY-139579) with good optical properties and targeting specificity for tumor tissues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S0456 Related Antibodies
Molecular Weight

953.44

Formula

C38H44ClN2Na3O12S4
CAS No.
Appearance

Solid

Color

Green to dark green

SMILES

O=[S](CCCCN(/C1=C/C=C(CCC2)/C(Cl)=C2/C=C/C(C(C)(C3=C4)C)=[N+](C3=CC=C4[S](=O)([O-])=O)CCCC[S](=O)(O[Na])=O)C(C(C1(C)C)=C5)=CC=C5[S](=O)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (34.96 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0488 mL 5.2442 mL 10.4883 mL
5 mM 0.2098 mL 1.0488 mL 2.0977 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.44%

SDS (252 KB)

COA (253 KB) HNMR (238 KB) RP-HPLC (357 KB) LCMS (142 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0488 mL 5.2442 mL 10.4883 mL 26.2208 mL
5 mM 0.2098 mL 1.0488 mL 2.0977 mL 5.2442 mL
10 mM 0.1049 mL 0.5244 mL 1.0488 mL 2.6221 mL
15 mM 0.0699 mL 0.3496 mL 0.6992 mL 1.7481 mL
20 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.3110 mL
25 mM 0.0420 mL 0.2098 mL 0.4195 mL 1.0488 mL
30 mM 0.0350 mL 0.1748 mL 0.3496 mL 0.8740 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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S0456 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S04561252007-83-2S 0456S-0456Fluorescent DyeDrug IntermediateDrug IintermediateNIRPafolacianinecanceroptical imaging agentraw materialInhibitorinhibitorinhibit

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