2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Antibody-Drug Conjugates (ADCs) TROP2
  4. Sacituzumab govitecan

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity.

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Sacituzumab govitecan Chemical Structure

Sacituzumab govitecan Chemical Structure

CAS No. : 1491917-83-9

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Based on 3 publication(s) in Google Scholar

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Description

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity[1].

In Vivo

Sacituzumab govitecan (IMMU-132) (17.5 mg/kg; twice weekly for 4 weeks) produces significant antitumor effects in mice bearing human gastric cancer xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

160000 (average)

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Sacituzumab govitecan]
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation

Purity: 98.00%

COA (231 KB)

Handling Instructions (2659 KB)
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Sacituzumab govitecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sacituzumab govitecan1491917-83-9IMMU-132IMMU132IMMU 132Antibody-Drug Conjugates (ADCs)TROP2Antibody-Drug ConjugatesEGP-1M1S1GA733-1antibody-drug conjugateSN-38pancreatic cancergastric cancerInhibitorinhibitorinhibit

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