2. Anti-infection
  3. Bacterial
  4. Salvinolone

Salvinolone is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Salvinolone shows cytotoxic activity with an IC50 of 47.6 μM against the HL-60 tumor cell line for 72 h.

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Salvinolone Chemical Structure

Salvinolone Chemical Structure

CAS No. : 120278-22-0

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Based on 1 publication(s) in Google Scholar

Salvinolone Related Antibodies

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Description

Salvinolone is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Salvinolone shows cytotoxic activity with an IC50 of 47.6 μM against the HL-60 tumor cell line for 72 h[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 15
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
BEAS-2B IC50
> 10 μM
Compound: 15
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
HL-60 IC50
> 10 μM
Compound: 15
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
MCF7 IC50
> 10 μM
Compound: 15
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
SMMC-7721 IC50
> 10 μM
Compound: 15
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
SW480 IC50
> 10 μM
Compound: 15
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
Molecular Weight

314.42

Formula

C20H26O3
CAS No.
SMILES

CC(C(C=C12)=C(O)C(O)=C2[C@@](C)(CCCC3(C)C)C3=CC1=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Salvinolone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Salvinolone120278-22-0BacterialMethicillinStaphylococcus aureusMRSAvancomycinEnterococcusVREHL-60Inhibitorinhibitorinhibit

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