2. GPCR/G Protein
  3. Angiotensin Receptor
  4. (Sar1,Ile4,8)-Angiotensin II

(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β.

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(Sar1,Ile4,8)-Angiotensin II Chemical Structure

(Sar1,Ile4,8)-Angiotensin II Chemical Structure

CAS No. : 185461-45-4

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Based on 1 publication(s) in Google Scholar

(Sar1,Ile4,8)-Angiotensin II Related Antibodies

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Description

(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β[1].

IC50 & Target[1]

Angiotensin II Type 1

 

In Vitro

(Sar1,Ile4,8)-Angiotensin II (30 μM; 30 min) increases the expression of insulin-stimulated phosphorylation of Akt and GSK3α/β in hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Sar1,Ile4,8)-Angiotensin II Related Antibodies
Molecular Weight

918.14

Formula

C43H75N13O9
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Sar}-Arg-Val-Ile-Ile-His-Pro-Ile
Sequence Shortening

{Sar}-RVIIHPI
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (108.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0892 mL 5.4458 mL 10.8916 mL
5 mM 0.2178 mL 1.0892 mL 2.1783 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0892 mL 5.4458 mL 10.8916 mL 27.2290 mL
5 mM 0.2178 mL 1.0892 mL 2.1783 mL 5.4458 mL
10 mM 0.1089 mL 0.5446 mL 1.0892 mL 2.7229 mL
15 mM 0.0726 mL 0.3631 mL 0.7261 mL 1.8153 mL
20 mM 0.0545 mL 0.2723 mL 0.5446 mL 1.3614 mL
25 mM 0.0436 mL 0.2178 mL 0.4357 mL 1.0892 mL
30 mM 0.0363 mL 0.1815 mL 0.3631 mL 0.9076 mL
40 mM 0.0272 mL 0.1361 mL 0.2723 mL 0.6807 mL
50 mM 0.0218 mL 0.1089 mL 0.2178 mL 0.5446 mL
60 mM 0.0182 mL 0.0908 mL 0.1815 mL 0.4538 mL
80 mM 0.0136 mL 0.0681 mL 0.1361 mL 0.3404 mL
100 mM 0.0109 mL 0.0545 mL 0.1089 mL 0.2723 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(Sar1,Ile4,8)-Angiotensin II Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Sar1,Ile4,8)-Angiotensin II185461-45-4Angiotensin Receptorhepatocytesp-Aktp-GSK3α/βglycogen synthesisinsulinInhibitorinhibitorinhibit

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