2. GPCR/G Protein
  3. Endothelin Receptor
  4. Sarafotoxin S6c

Sarafotoxin S6c  (Synonyms: SRTX-c)

Cat. No.: HY-102029 Purity: 98.19%
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Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels.

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Sarafotoxin S6c Chemical Structure

Sarafotoxin S6c Chemical Structure

CAS No. : 121695-87-2

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Based on 1 publication(s) in Google Scholar

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Description

Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

IC50 & Target

Endothelin-B receptor[1]
In Vivo

Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks[1]
Dosage: 1 pM-1 mM
Administration:
Result: Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident.
Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.
Molecular Weight

2515.75

Formula

C103H147N27O37S5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: Cys1-Cys15; Cys3-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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Sarafotoxin S6c Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sarafotoxin S6c121695-87-2SRTX-cEndothelin ReceptorInhibitorinhibitorinhibit

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