Sarafotoxin S6d  (Synonyms: STX-b)

Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases^[1].

Sarafotoxin S6d (0.3, 1.0, 3.0 and 5.0 nmol/kg; i.v.) can produce a constant pressure effect and a short pulse pressure increase at 0.3-3.0 nmol/kg. However, at 5.0 nmol/kg, Sarafotoxin S6d can cause a rapid drop in blood pressure, heart rate, and breathing rate after an initial increase, leading to the deaths of most mice within 10 minutes^[1].
Sarafotoxin S6d (5.0 nmol/kg; i.v.) increases K⁺ levels by 159% significantly. Additionally, plasma enzymes (LDH, CPK), IP, and glucose levels are also significantly elevated. LDH increases by 60%, CPK by 91%, IP by 137%, and glucose by 80%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2591.98

C₁₁₂H₁₆₃N₂₇O₃₄S₅

1446991-36-1

Cys-Thr-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Ile-Ile-Trp (disulfide bridge: Cys1-Cys15, Cys3-Cys11)

CTCKDMTDKECLYFCHQDIIW (disulfide bridge: Cys1-Cys15, Cys3-Cys11)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lin W W, et al. Cardiovascular effects of two disulfide analogues of sarafotoxin S6b[J]. Toxicon, 1990, 28(8): 911-923.  [Content Brief]