SB-236057

Cat. No.: HY-116603: FAQs
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SB-236057 is an inverse agonist of the 5-HT_1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis.

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SB-236057 Chemical Structure

CAS No. : 180083-49-2

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Description	SB-236057 is an inverse agonist of the 5-HT_1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis^[1].
Molecular Weight	534.65
Formula	C₃₃H₃₄N₄O₃
CAS No.	180083-49-2
SMILES	O=C(N1C2=CC3=C(C=C2CC1)OCC34CCN(CC4)CC)C5=CC=C(C6=C(C)C=C(C7=NN=C(C)O7)C=C6)C=C5
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Augustine‐Rauch K A, et al. Evidence for a molecular mechanism of teratogenicity of SB‐236057, a 5‐HT1B receptor inverse agonist that alters axial formation[J]. Birth Defects Research Part A: Clinical and Molecular Teratology, 2004, 70(10): 789-807. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-236057180083-49-2SB236057SB 2360575-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInverse agonistsskeletal teratogensembryonic developmentsomatic patterningtail extension defectsInhibitorinhibitorinhibit

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SB-236057

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