2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB 258741 hydrochloride

SB 258741 hydrochloride is a specific 5-HT7 receptor antagonist and can be used for the research of schizophrenia.

For research use only. We do not sell to patients.

SB 258741 hydrochloride Chemical Structure

SB 258741 hydrochloride Chemical Structure

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SB 258741 hydrochloride Related Antibodies

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Description

SB 258741 hydrochloride is a specific 5-HT7 receptor antagonist and can be used for the research of schizophrenia[1].

IC50 & Target

5-HT7 Receptor

 

In Vitro

SB-258741 behaves as a partial inverse agonist, the antagonist potency (apparent pKB) is 8.47[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB 258741 hydrochloride Related Antibodies
In Vivo

SB 258741 (0-9.1 mg/kg; s.c.; once or daily for 3 days) shows antipsychotic effects in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats, 250 –300 g in the phencyclidine (PCP)-disrupted prepulse inhibition (PPI) and PCP-disrupted social interaction (SIT) paradigm, 200 – 250 g in the catalepsy, motility, and D-amphetamine hyperactivity paradigms[1]
Dosage: 0.56, 2.3, 4.6 and 9.1 mg/kg
Administration: Subcutaneous injection, once or daily for 3 days (social interaction test)
Result: Reversed hyperactivity induced by D-amphet-amine over 0.56 mg/kg, and reduced motility at 4.6 and 9.1 mg/kg.
Did not reverse D-Amphetamine-disrupted PPI, but enhanced PCP-disrupted PPI.
Reduced PCP (2 mg/kg)-induced hyperactivity.
Molecular Weight

386.98

Formula

C19H31ClN2O2S
SMILES

O=S(N1[C@@H](CCN2CCC(C)CC2)CCC1)(C3=CC=CC(C)=C3)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB 258741 hydrochloride Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB 258741SB258741SB-2587415-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorschizophreniaprepulse inhibitionInhibitorinhibitorinhibit

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SB 258741 hydrochloride
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