Scio-323

Cat. No.: HY-167679: Data Sheet Handling Instructions Technical Support

Scio-323 is an orally available p38 mitogen-activated protein kinase (MAPK) inhibitor with the potential to inhibit chronic inflammatory responses associated with polyethylene particles. Scio-323's oral inhibition pattern had a minimal effect on bone formation. Scio-323 administration inhibited net bone formation after the establishment of a chronic inflammatory response to polyethylene particles. Osteoblast-like activity remained low in all cases of Scio-323 inhibition. Scio-323 failed to improve bone growth in the presence of polyethylene particles.

For research use only. We do not sell to patients.

Scio-323 Chemical Structure

CAS No. : 309913-51-7

Size	Price	Stock	Quantity
1 mg	USD 358	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
5 mg	USD 798	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
10 mg	USD 1180	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
25 mg	USD 1884	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	2 - 3 weeks
50 mg		Get quote
100 mg		Get quote

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Description	Scio-323 is an orally available p38 mitogen-activated protein kinase (MAPK) inhibitor with the potential to inhibit chronic inflammatory responses associated with polyethylene particles. Scio-323's oral inhibition pattern had a minimal effect on bone formation. Scio-323 administration inhibited net bone formation after the establishment of a chronic inflammatory response to polyethylene particles. Osteoblast-like activity remained low in all cases of Scio-323 inhibition. Scio-323 failed to improve bone growth in the presence of polyethylene particles^[1].
Molecular Weight	479.54
Formula	C₂₇H₃₀FN₃O₄
CAS No.	309913-51-7
SMILES	O=C(C1=CN(C)C2=C1C=C(C(N3CCC(CC3)CC4=CC=C(C=C4)F)=O)C(OC)=C2)C(N(C)C)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo

Scio-323 Related Classifications

Inflammation/Immunology

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Keywords:

Scio-323309913-51-7Scio323Scio 323Endogenous MetaboliteInhibitorinhibitorinhibit

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Scio-323

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