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Natural Product-like Compound Library

Cat. No.: HY-L905

Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.

MCE 5K Natural Product-like Compound Library consists of 5,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

  • Description & Advantages
  • Documentation

Description & Advantages

•    A unique collection of natural product-like compound library.

•    Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with 40K natural products, and natural-likeness scoring is more than -2.

•    Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

•    Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•    All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   NMR and HPLC validated to ensure high purity and quality.

Product Details

•    A unique collection of natural product-like compound library.

•    Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with 40K natural products, and natural-likeness scoring is more than -2.

•    Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2

•    Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.

•    All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.

•   NMR and HPLC validated to ensure high purity and quality.

Documentation

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    Product Name:
    Natural Product-like Compound Library
    Cat. No.:
    HY-L905
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack