SDH-IN-15 

SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death^[1].

SDH-IN-15 shows antifungal activity of EC₅₀=0.039 μg/mL (R. solani); 0.426 μg/mL (S. sclerotiorum); and 3.482 μg/mL (B. cinerea), respectively. Superior to Boscalid (HY-119976) and Fluxapyroxad (HY-135549)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SDH-IN-15 (100 μg/mL; 5 days) shows a significant inhibitory effect on the growth of R. solani on rice leaves with a protection efficiency of 86.8%, which is significantly better than the control drugs Boscalid (HY-119976) (68.1%) and Fluxapyroxad (HY-135549) (80.6%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

477.30

C₂₁H₁₉BrF₂N₄O₂

O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2/C(C)=N/OCC3=CC=C(Br)C=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Luo B, et al. Novel Pyrazole-4-Carboxamide Derivatives Containing Oxime Ether Group as Potential SDHIs to Control Rhizoctonia solani. J Agric Food Chem. 2024 May 1;72(17):9599-9610.  [Content Brief]