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Isoforms Recommended: IRAK4
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Irak4

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  • HY-P73255
    IRAK4 Protein, Human (sf9, His)

    Interleukin-1 receptor-associated kinase 4; IPD1; Irak4; NY-REN-64; REN64

    		 Human Sf9 insect cells
    IRAK4 Protein, a serine/threonine-protein kinase, is pivotal in initiating innate immune responses via Toll-like receptor (TLR) and IL-1R signaling pathways. Upon TLR activation, it rapidly forms the Myddosome with IRAK2. IRAK4 phosphorylates IRAK1, promoting its autophosphorylation, and phosphorylates Pellino proteins to facilitate IRAK1 polyubiquitination. This leads to NF-kappa-B activation and regulates immune responses during microbial infections. Additionally, it phosphorylates TIRAP, influencing its ubiquitination and degradation. IRAK4 Protein, Human (sf9, His) is the recombinant human-derived IRAK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of IRAK4 Protein, Human (sf9, His) is 460 a.a., with molecular weight of ~48 kDa.
  • HY-P702732
    IRAK4 Protein, Human (307a.a, sf9, His)

    Interleukin-1 receptor-associated kinase 4; IPD1; Irak4; NY-REN-64; REN64

    		 Human Sf9 insect cells
    The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 Protein, Human (307a.a, sf9, His) is the recombinant human-derived IRAK4, expressed by Sf9 insect cells , with His labeled tag. ,

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