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Results for "

BSO

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

MCE Kits

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106376
    DL-Buthionine-(S,R)-sulfoximine
    Maximum Cited Publications
    18 Publications Verification

    Buthionine sulfoximine; BSO

    		 Ferroptosis Cancer
    DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
    DL-Buthionine-(S,R)-sulfoximine
  • HY-106376B
    DL-Buthionine-(S,R)-sulfoximine hydrochloride
    Maximum Cited Publications
    18 Publications Verification

    Buthionine sulfoximine hydrochloride; BSO hydrochloride

    		 Ferroptosis Cancer
    DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
    DL-Buthionine-(S,R)-sulfoximine hydrochloride
  • HY-106376A
    L-Buthionine-(S,R)-sulfoximine
    5+ Cited Publications

    L-Buthionine sulfoximine; L-BSO

    		 Ferroptosis Cancer
    L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
    L-Buthionine-(S,R)-sulfoximine
  • HY-106376C
    L-Buthionine-(S,R)-sulfoximine hydrochloride
    5+ Cited Publications

    L-Buthionine sulfoximine hydrochloride; L-BSO hydrochloride

    		 Ferroptosis Metabolic Disease Cancer
    L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively .
    L-Buthionine-(S,R)-sulfoximine hydrochloride
  • HY-162886
    BSO-07

    		JNK Reactive Oxygen Species Cancer
    BSO-07 is a ROS/JNK activator with significant anticancer effects, having an IC50 value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating JNK and increasing ROS levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer .
    BSO-07
  • HY-158740
    1(R)-(Trifluoromethyl)oleyl alcohol

    		Ferroptosis Neurological Disease
    1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) is a trifluoromethyl alcohol derivative of Oleic acid (HY-N1446) with activity in multiple models of Friedreich ataxia (FRDA). 1(R)-(Trifluoromethyl)oleyl alcohol inhibits ferroptosis induced by Erastin (HY-15763) and decreases lipid peroxidation in NBT human myoblasts with frataxin (FXN) siRNA knockdown. 1(R)-(Trifluoromethyl)oleyl alcohol at 40 μM increases survival to 95% in a model of FRDA where a significant percentage of cell death is caused by FAC (HY-B1645) and BSO (HY-106376) .
    1(R)-(Trifluoromethyl)oleyl alcohol

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