2. Apoptosis
  3. Ferroptosis
  4. DL-Buthionine-(S,R)-sulfoximine hydrochloride

DL-Buthionine-(S,R)-sulfoximine hydrochloride  (Synonyms: Buthionine sulfoximine hydrochloride; BSO hydrochloride)

Cat. No.: HY-106376B Purity: ≥98.0%
SDS COA Handling Instructions

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DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

For research use only. We do not sell to patients.

DL-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure

DL-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 39 In-stock
Solution
10 mM * 1 mL in Water USD 39 In-stock
Solid
25 mg USD 35 In-stock
50 mg USD 60 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of DL-Buthionine-(S,R)-sulfoximine hydrochloride:

DL-Buthionine-(S,R)-sulfoximine hydrochloride Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

IC50 & Target

Glutamylcysteine synthetase[1]
In Vitro

Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Buthionine-(S,R)-sulfoximine hydrochloride Related Antibodies
In Vivo

Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

258.77

Formula

C8H19ClN2O3S
Appearance

Solid

Color

White to off-white

SMILES

OC(C(N)CCS(CCCC)(=N)=O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (386.44 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8644 mL 19.3222 mL 38.6444 mL
5 mM 0.7729 mL 3.8644 mL 7.7289 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (386.44 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (246 KB) HNMR (256 KB) MS (181 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.8644 mL 19.3222 mL 38.6444 mL 96.6109 mL
5 mM 0.7729 mL 3.8644 mL 7.7289 mL 19.3222 mL
10 mM 0.3864 mL 1.9322 mL 3.8644 mL 9.6611 mL
15 mM 0.2576 mL 1.2881 mL 2.5763 mL 6.4407 mL
20 mM 0.1932 mL 0.9661 mL 1.9322 mL 4.8305 mL
25 mM 0.1546 mL 0.7729 mL 1.5458 mL 3.8644 mL
30 mM 0.1288 mL 0.6441 mL 1.2881 mL 3.2204 mL
40 mM 0.0966 mL 0.4831 mL 0.9661 mL 2.4153 mL
50 mM 0.0773 mL 0.3864 mL 0.7729 mL 1.9322 mL
60 mM 0.0644 mL 0.3220 mL 0.6441 mL 1.6102 mL
80 mM 0.0483 mL 0.2415 mL 0.4831 mL 1.2076 mL
100 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9661 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DL-Buthionine-(S,R)-sulfoximine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Buthionine-(S,R)-sulfoximineButhionine sulfoximineBSOFerroptosisInhibitorinhibitorinhibit

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