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Results for "

ADAMTS4

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

4

Peptides

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P5419A
    WAAG-3R TFA

    		Biochemical Assay Reagents Others
    WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)
    WAAG-3R TFA
  • HY-P10398
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA

    		ADAMTS Others
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity .
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA
  • HY-114996
    ADAMTS-5 Inhibitor
    3 Publications Verification

    		 ADAMTS Inflammation/Immunology
    ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .
    ADAMTS-5 Inhibitor
  • HY-137430
    Aldumastat

    GLPG1972; S201086

    		 ADAMTS Metabolic Disease
    Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .
    Aldumastat
  • HY-145061
    ADAMTS-5-IN-3

    		ADAMTS Metabolic Disease Inflammation/Immunology
    ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .
    ADAMTS-5-IN-3
  • HY-101448
    TMI-1

    WAY-171318

    		 MMP Apoptosis Interleukin Related TNF Receptor Caspase Infection Neurological Disease Inflammation/Immunology Cancer
    TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions [4].
    TMI-1
  • HY-RS00304
    ADAMTS4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADAMTS4 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADAMTS4 Human Pre-designed siRNA Set A
    ADAMTS4 Human Pre-designed siRNA Set A
  • HY-160822
    AGG-523

    PF-5212371

    		 ADAMTS Inflammation/Immunology
    AGG-523 (PF-5212371) is a reversible, non-hydroxamate, zinc-binding selective aggrecanase 1 (ADAMTS4) and aggrecanase 2 (ADAMTS5) inhibitor. AGG-523 can be used for the study of osteoarthritis (OA) .
    AGG-523
  • HY-P10468
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2

    		ADAMTS Others
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity .
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2

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