2. Metabolic Enzyme/Protease
  3. ADAMTS
  4. ADAMTS-5 Inhibitor

ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).

For research use only. We do not sell to patients.

ADAMTS-5 Inhibitor Chemical Structure

ADAMTS-5 Inhibitor Chemical Structure

CAS No. : 929634-33-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid
1 mg USD 60 In-stock
5 mg USD 150 In-stock
10 mg USD 220 In-stock
50 mg USD 550 In-stock
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Based on 3 publication(s) in Google Scholar

ADAMTS-5 Inhibitor Related Antibodies

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Description

ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1)[1].

In Vitro

ADAMTS-5 (aggrecanase-2) is an extracellular matrix-degrading protease implicated in cartilage destruction in arthritis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADAMTS-5 Inhibitor Related Antibodies
Molecular Weight

449.92

Formula

C16H11ClF3N3OS3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC(S/C1=C\C2=C(SCC3=CC=C(Cl)C=C3)N(C)N=C2C(F)(F)F)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (185.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2226 mL 11.1131 mL 22.2262 mL
5 mM 0.4445 mL 2.2226 mL 4.4452 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2226 mL 11.1131 mL 22.2262 mL 55.5654 mL
5 mM 0.4445 mL 2.2226 mL 4.4452 mL 11.1131 mL
10 mM 0.2223 mL 1.1113 mL 2.2226 mL 5.5565 mL
15 mM 0.1482 mL 0.7409 mL 1.4817 mL 3.7044 mL
20 mM 0.1111 mL 0.5557 mL 1.1113 mL 2.7783 mL
25 mM 0.0889 mL 0.4445 mL 0.8890 mL 2.2226 mL
30 mM 0.0741 mL 0.3704 mL 0.7409 mL 1.8522 mL
40 mM 0.0556 mL 0.2778 mL 0.5557 mL 1.3891 mL
50 mM 0.0445 mL 0.2223 mL 0.4445 mL 1.1113 mL
60 mM 0.0370 mL 0.1852 mL 0.3704 mL 0.9261 mL
80 mM 0.0278 mL 0.1389 mL 0.2778 mL 0.6946 mL
100 mM 0.0222 mL 0.1111 mL 0.2223 mL 0.5557 mL
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ADAMTS-5 Inhibitor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADAMTS-5 Inhibitor929634-33-3ADAMTSAdamalysin-like metalloproteinase with thrombospondin motifsextracellularmatrix-degradingproteasecartilagedestructionarthritisInhibitorinhibitorinhibit

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