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ALK/ROS1-IN-5

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-170418
    ALK/ROS1-IN-5

    		Anaplastic lymphoma kinase (ALK) ROS Kinase Apoptosis Cancer
    ALK/ROS1-IN-5 (compound X4) is a selective ALK and ROS1 kinases inhibitor with IC50s of 0.512 μM (ALK), 0.766 μM (ROS1), respectively. ALK/ROS1-IN-5 inhibits H2228 cells with an IC50 of 0.034 μM. ALK/ROS1-IN-5 induces cancer cells apoptosis in dose-dependent manner. ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells[1].
    ALK/ROS1-IN-5

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