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Benzylguanine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Apoptosis (1) DNA/RNA Synthesis (1)
By Research Areas:	Cancer (1)
Click Chemistry:	Labeling and Fluorescence Imaging (2) Alkynes (2)

3

Inhibitors & Agonists

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Peptides

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

O6-Benzylguanine 1 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .

Alkyne-PEG5-SNAP Alkyne-PEG5-BG	ADC Linker	Others
Alkyne-PEG5-SNAP is a click chemistry reagent containing an alkyne group. Alkyne-PEG5-SNAP can alkyne conjugated benzylguanine (BG), the BG moiety reacts specifically and rapidly with SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality suitable for further conjugation . Alkyne-PEG5-SNAP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Alkyne-SNAP	ADC Linker	Others
Alkyne-SNAP (compound 3) is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation .

Cat. No.	Product Name	Target	Research Area

[Cys(Bzl)84] CD (81-92)	Peptides	Others
[Cys(Bzl)84] CD (81-92) is an acidic peptide. [Cys(Bzl)84] CD (81-92) can be sequencing by negative ion postsource decay (PSD) spectra .

Cat. No.	Product Name		Classification

Alkyne-PEG5-SNAP Alkyne-PEG5-BG		Alkynes Labeling and Fluorescence Imaging
Alkyne-PEG5-SNAP is a click chemistry reagent containing an alkyne group. Alkyne-PEG5-SNAP can alkyne conjugated benzylguanine (BG), the BG moiety reacts specifically and rapidly with SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality suitable for further conjugation . Alkyne-PEG5-SNAP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Alkyne-SNAP		Alkynes Labeling and Fluorescence Imaging
Alkyne-SNAP (compound 3) is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation .

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