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Bfl-1-IN-3

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162642
    Bfl-1-IN-3

    		Bcl-2 Family Cancer
    Bfl-1-IN-3 (Compound 56) is a selective, competitive inhibitor for Bfl-1 on BID binding site with Ki of 105 nM. Bfl-1-IN-3 inhibits the proliferation of cell pfeiffer and MV4-11, with IC50 of 6.92 μM and 12.6 μM. Bfl-1-IN-3 induces apoptosis in pfeiffer cells. Bfl-1-IN-3 overcomes Venetoclax (HY-15531) resistance at the cellular level, and shows synergistically enhanced anti-tumor activity with Venetoclax .
    Bfl-1-IN-3

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