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Results for "

Cobimetinib

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13064
    Cobimetinib
    40+ Cited Publications

    GDC-0973; XL518

    		 MEK Apoptosis Cancer
    Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1.
    Cobimetinib
  • HY-13078
    Cobimetinib racemate

    GDC-0973 racemate; XL518 racemate

    		 MEK Cancer
    Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.
    Cobimetinib racemate
  • HY-13079
    Cobimetinib (R-enantiomer)

    GDC-0973 (R-enantiomer); XL-518 (R-enantiomer)

    		 MEK Cancer
    Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.
    Cobimetinib (R-enantiomer)
  • HY-13064A
    Cobimetinib hemifumarate
    40+ Cited Publications

    GDC-0973 hemifumarate; XL-518 hemifumarate

    		 MEK Apoptosis Cancer
    Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM.
    Cobimetinib hemifumarate
  • HY-142160
    GNE-9815

    		Raf Cancer
    GNE-9815 (compound 7) is a highly selective, pan-RAF inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for CRAF and BRAF, respectively. GNE-9815 combines with MEK inhibitor Cobimetinib (HY-13064) shows synergistic modulation of MAPK pathway. GNE-9815 can be used in studies of KRAS mutant cancers .
    GNE-9815
  • HY-13064S1
    Cobimetinib-d4 hydrochloride

    GDC-0973-d4 hydrochloride; XL518-d4 hydrochloride

    		 MEK Apoptosis Isotope-Labeled Compounds Cancer
    Cobimetinib-d4 hydrochloride is deuterated labeled Cobimetinib (HY-13064). Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1.
    Cobimetinib-d4 hydrochloride
  • HY-13078S
    Cobimetinib-13C6 racemate

    GDC-0973-13C66 racemate; XL518-13C6 racemate

    		 Isotope-Labeled Compounds Others
    Cobimetinib- 13C6 (GDC-0973- 13C6; XL518- 13C6) racemateis the deuterium labeledCobimetinib (racemate)(HY-13078) . Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor .
    Cobimetinib-13C6 racemate
  • HY-160414
    TRX-COBI

    (R,R)-TRX-COBI; TRX-Cobimetinib

    		 MEK Cancer
    TRX-COBI ((R,R)-TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe 2+. TRX-COBI has antitumor activity .
    TRX-COBI

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