DLK

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Insulin Receptor (1) JNK (2) MAP3K (5) Notch (1) p38 MAPK (1) Small Interfering RNA (siRNA) (2) Tie (1) VEGFR (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Neurological Disease (7)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114331

DLK-IN-1	MAP3K	Neurological Disease
DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase *(DLK, MAP3K12), with a K_i* of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

HY-148629

GDC-0134	JNK	Neurological Disease
GDC-0134 is a potent, selective, orally active, brain-penetrant dual leucine zipper kinase (DLK) inhibitor. GDC-0134 blocks DLK activity in cellular assays and in animal models of neuronal injury. GDC-0134 can be used for the study of amyotrophic lateral sclerosis (ALS) .

HY-114332

GNE-8505	MAP3K	Neurological Disease
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK) .

HY-12947

GNE-3511 5+ Cited Publications	MAP3K	Neurological Disease
GNE-3511 is an orally active bioavailable and brain-penetrant dual leucine zipper kinase (DLK) inhibitor with a K_i of 0.5 nM. GNE-3511 can cross the blood-brain-barrier and can be used for the research of neurodegenerative diseases .

HY-152142

DN-1289	JNK	Neurological Disease
DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC₅₀=17 nM) and leucine zipper-bearing kinase (LZK; IC₅₀=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability .

HY-RS03806

DLK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DLK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DLK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DLK1 Human Pre-designed siRNA Set A DLK1 Human Pre-designed siRNA Set A

HY-RS03807

DLK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DLK2 Human Pre-designed siRNA Set A contains three designed siRNAs for DLK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DLK2 Human Pre-designed siRNA Set A DLK2 Human Pre-designed siRNA Set A

HY-14243

CEP-14083	Anaplastic lymphoma kinase (ALK) Insulin Receptor VEGFR Tie	Cancer
CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC₅₀ value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma .

HY-155089

IACS-52825	MAP3K	Neurological Disease
IACS-52825 is a potent and selective *DLK* inhibitor with K_d of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy .

HY-170484

KAI-11101	MAP3K p38 MAPK	Neurological Disease
KAI-11101 is the inhibitor for dual leucine zipper kinase (DLK, MAP3K12) with a K_i of 0.7 nM. KAI-11101 inhibits Paclitaxel (HY-B0015)-induced cJun phosphorylation (IC₅₀=95 nM) and thus inhibits the activation of MAPK pathway. KAI-11101 is blood brain barrier penetrable and can be further investigated for its neuroprotective property .

HY-P990613

LIV-1205 (CBA-1205) CBA-1205	Notch	Inflammation/Immunology
LIV-1205 (CBA-1205) is a humanized antibody expressed in CHO cells that targets *DLK1*. LIV-1205 (CBA-1205) contains a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for LIV-1205 (CBA-1205) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Target	Research Area

HY-P990613

LIV-1205 (CBA-1205) CBA-1205	Notch	Inflammation/Immunology
LIV-1205 (CBA-1205) is a humanized antibody expressed in CHO cells that targets *DLK1*. LIV-1205 (CBA-1205) contains a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for LIV-1205 (CBA-1205) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (4) Mouse (2) Cynomolgus (1)
Tag:	His (5) GST (1) Fc (1)
Source:	HEK293 (5) P. pastoris (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70138

	DLK-1 Protein, Human (S260N, HEK293, His) rHuDelta-like 1 homolog/DLK-1, His; Protein Delta Homolog 1; DLK-1; pG2; DLK1; DLK	Human	HEK293
	DLK-1 Protein is implicated in neuroendocrine differentiation, signifying its role in cellular specialization. It acts as an inhibitor of adipocyte differentiation, regulating adipogenesis. Structurally, DLK-1 exists as a monomer, defining its molecular composition in these processes. Interactions with SH3RF2 underscore its engagement with cellular components and potential regulatory pathways. DLK-1 Protein, Human (S260N, HEK293, His) is the recombinant human-derived DLK-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DLK-1 Protein, Human (S260N, HEK293, His) is 274 a.a., with molecular weight of 35-45 kDa.

HY-P77915

	DLK-1 Protein, Mouse (HEK293, His) pG2; FA1; DLK; DLK1; DLK-1; Pref1; secredeltin; ZOG	Mouse	HEK293
	DLK-1 Protein is implicated in neuroendocrine differentiation, signifying its role in cellular specialization. It acts as an inhibitor of adipocyte differentiation, regulating adipogenesis. Structurally, DLK-1 exists as a monomer, defining its molecular composition in these processes. Interactions with SH3RF2 underscore its engagement with cellular components and potential regulatory pathways. DLK-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DLK-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77914

	DLK-1 Protein, Human (HEK293, His) pG2; FA1; DLK; DLK1; DLK-1; Pref1; secredeltin; ZOG	Human	HEK293
	The DLK-1 protein has been implicated in neuroendocrine differentiation, suggesting a role in the complex processes that control neuroendocrine cell development and specialization. As a monomer, the single molecular form of DLK-1 helps carry out its biological activity. DLK-1 Protein, Human (HEK293, His) is the recombinant human-derived DLK-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DLK-1 Protein, Human (HEK293, His) is 280 a.a., with molecular weight of 40-50 kDa.

HY-P700706

	DLK-1 Protein, Cynomolgus (HEK293, His) pG2; FA1; DLK; DLK1; DLK-1; Pref1; secredeltin; ZOG	Cynomolgus	HEK293
	DLK-1, also known as pre adipokine, is a transmembrane-secreted protein with an epidermal growth factor (EGF) -like repeat sequence. DLK-1 regulates the growth of pioneer axons by controlling Wnt signaling. DLK-1 is a cell surface protein expressed in many cancers, including hepatocellular carcinoma, and maybe a potential target for monoclonal antibodies to treat cancer. DLK-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived DLK-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DLK-1 Protein, Cynomolgus (HEK293, His) is 283 a.a., with molecular weight of 42-52 kDa.

HY-P700856

	DLK-1 Protein, Human (HEK293, hFc) pG2; FA1; DLK; DLK1; DLK-1; Pref1; secredeltin; ZOG	Human	HEK293
	The DLK-1 protein has been implicated in neuroendocrine differentiation, suggesting a role in the complex processes that control neuroendocrine cell development and specialization. As a monomer, the single molecular form of DLK-1 helps carry out its biological activity. DLK-1 Protein, Human (HEK293, hFc) is the recombinant human-derived DLK-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DLK-1 Protein, Human (HEK293, hFc) is 280 a.a., with molecular weight of 70-80 kDa.

HY-P702629

	DLK2 Protein, Mouse (P.pastoris, His) Protein delta homolog 2; Epidermal growth factor-like protein 9 (EGF-like protein 9); Endothelial cell-specific protein S-1; Egfl9	Mouse	P. pastoris
	DLK2 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived DLK2, expressed by P. pastoris , with N-6*His labeled tag. The total length of DLK2 Protein, Mouse (P.pastoris, His) is 279 a.a.,

HY-P77286

	DAPK3/ZIPK Protein, Human (sf9, GST) Death-associated protein kinase 3; DAP kinase 3; DLK; MYPT1 kinase; ZIPK	Human	Sf9 insect cells
	The DAPK3/ZIPK protein is a multifunctional serine/threonine kinase that complexly regulates apoptosis, autophagy, transcription, translation, and actin cytoskeletal reorganization. Its key roles include coordinating apoptotic and autophagy signaling, influencing smooth muscle contraction, and regulating starvation-induced autophagy. DAPK3/ZIPK Protein, Human (sf9, GST) is the recombinant human-derived DAPK3/ZIPK protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of DAPK3/ZIPK Protein, Human (sf9, GST) is 454 a.a., with molecular weight of ~70 kDa.

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HY-P83574

	DAP kinase 3 Antibody (YA3319) DAPK3; ZIPK; Death-associated protein kinase 3; DAP kinase 3; DAP-like kinase; DLK; MYPT1 kinase; Zipper-interacting protein kinase; ZIP-kinase	WB	Human
	DAP kinase 3 Antibody (YA3319) is a biotin-conjugated non-conjugated IgG antibody, targeting DAP kinase 3, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). DAP kinase 3 Antibody (YA3319) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS03806

DLK1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
DLK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DLK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03807

DLK2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
DLK2 Human Pre-designed siRNA Set A contains three designed siRNAs for DLK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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